Haspin Kinase
Haspin is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. Haspin expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. Haspin phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion of Haspin by RNA interference reveals that Haspin is required for H3 thr3 phosphorylation in mitotic cells. Phosphorylation of H3T3ph by Haspin is necessary for chromosomal passenger complex (CPC) accumulation at centromeres. H3T3ph then positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis.
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Haspin Kinase Related Products (17)
Related Products (17)
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INE963
0 ImagesINE963 is a potent and fast-acting blood-stage antimalarial agent, with an EC50s of 3-6 nM. INE963 is potential for single-dose cures in uncomplicated malaria.
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Haspin-IN-3
0 ImagesHaspin-IN-3 (compound 8l) is a potent haspin inhibitor with IC50 of 14 nM. Haspin-IN-3 has anticancer effects.
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LDN-209929 dihydrochloride
0 ImagesLDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455).
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MELK-8a
0 ImagesSynonyms: NVS-MELK8aMELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells.
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MU1920
0 ImagesMU1920 is an ATP-competitive, selective inhibitor for haspin with an IC50 of 6 nM. MU1920 exhibits good pharmacokinetic properties and metabolic stability in mouse plasma and microsomes without obvious anticancer effects, which can be used for development of chemical probes.
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Haspin-IN-2
0 ImagesCat. No.: HY-146587CAS No.: 2768474-47-9Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively.
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Haspin-IN-4
0 ImagesCat. No.: HY-163858Haspin-IN-4 (Compound 60) is a selective inhibitor of Haspin with an IC50 value of 0.01 nM. Haspin-IN-4 possesses anticancer activity and can be used in cancer research.
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Anticancer agent 285
0 ImagesCat. No.: HY-179486CAS No.: 2878446-03-6Anticancer agent 285 is an orally active anticancer agent with highly effective and selective haspin-inhibiting IC50 = 18 nM) activity. Anticancer agent 285 can be used for the study of colorectal cancer[1].
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Haspin-IN-1
0 ImagesCat. No.: HY-146586CAS No.: 2768474-30-0Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC50 of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 221 nM and 916.3 nM, respectively.
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CHR-6494 TFA
0 ImagesCat. No.: HY-110350CAS No.: 1458630-17-5
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LDN-209929
0 ImagesCat. No.: HY-135002CAS No.: 1233355-57-1LDN-209929 is a potent haspin kinase inhibitor, with IC50 values of 55 nM and 9.9 μM for Haspin and DYRK2, respectively.
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FLT3-IN-38
0 ImagesCat. No.: HY-112366CAS No.: 896138-40-2FLT3-IN-38 (Flt-3 Inhibitor II) is a FLT3 inhibitor. FLT3-IN-38 has off-target effects and inhibits serine/threonine kinase haspin. Haspin is a mitotic signal coordinator. FLT3-IN-38 can be used for cancer research.
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